Auto immune diseases, medication, limited mobility, genetics, hormones.. yup. All have effected my weight and not in a good way.
However, I have found some wonderful basic mobility exercises made specifically for sedentary people that I can do regularly. Granted, it isn't going to help with any weight loss, but in the long run, it has been absolutely astounding, how much more easily I can move now, which lends itself to being able to move longer, get my stamina back.. baby steps to get to where I want to be.. and even if those steps look more like crawling, it's so necessary to start slow, get the muscles fired up and used to working again. Little by little, those 15 minute exercises that you struggled through, now you are looking to add another 15 minutes to your exercise.
Now the problem is my diet. Portion sizes to be exact. And I eat WAY too fast, a habit I developed in high school, being involved in band, drama, choir etc.. Led to only having 5 minutes for lunch, rushed dinners to get to rehearsals etc.. So changing behaviors is also key for me... I am getting there.. slowly.. but I make progress every day, even if it's just putting my sneakers on, or throwing last night's left over veggies into an omelet for breakfast.. small changes lead to big results over time..